Sample Size Estimation for Bio-Equivalence Trials Through Simulation

---

Documentation for package ‘SimTOST’ version 1.0.2

• DESCRIPTION file.
• User guides, package vignettes and other documentation.
• Package NEWS.

Help Pages

SimTOST-package	Sample Size Estimation via Simulation
get_par	Parameter Configuration for Endpoints and Comparators
plot.simss	Plot Power vs Sample Size for Simulation Results
power_dom	Power Calculation for Difference of Means (DOM) Hypothesis Test
print.simss	Print Summary of Sample Size Estimation
run_simulations_2x2_dom	Run Simulations for a 2x2 Crossover Design with Difference of Means (DOM) test
run_simulations_2x2_rom	Run Simulations for a 2x2 Crossover Design with Ratio of Means (ROM) test
run_simulations_par_dom	Run Simulations for a Parallel Design with Difference of Means (DOM) test
run_simulations_par_rom	Run Simulations for a Parallel Design with Ratio of Means (ROM) test
sampleSize	Sample Size Calculation for Bioequivalence and Multi-Endpoint Studies
sampleSize_Mielke	Sample Size Estimation for Multiple Hypothesis Testing Using Mielke's Method
simParallelEndpoints	Generate Simulated Endpoint Data for Parallel Group Design
SimTOST	Sample Size Estimation via Simulation
test_2x2_dom	Simulate a 2x2 Crossover Design and Compute Difference of Means (DOM)
test_2x2_rom	Simulate a 2x2 Crossover Design and Compute Ratio of Means (ROM)
test_par_dom	Simulate a Parallel Design and Test Difference of Means (DOM)
test_par_rom	Simulate a Parallel Design and Test Ratio of Means (ROM)